November 2, 2009

CORRESPONDENCE

Reply to A. Sánchez-Muñoz et al

Filippo Montemurro, Lucia Del Mastro, and Massimo Aglietta
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4326 [Abstract] [PDF]  

CORRESPONDENCE

Reply to Aragon-Ching

Shabbir M.H. Alibhai
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4300 [Abstract] [PDF]  

CORRESPONDENCE

Reply to T. Grenader et al

Sao Jiralerspong and Ana M. Gonzalez-Angulo
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4292 [Abstract] [PDF]  

CORRESPONDENCE

Reply to K. Satharasinghe et al

Brian H. Kushner, Kim Kramer, Shakeel Modak, and Nai-Kong V. Cheung
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4144 [Abstract] [PDF]  

CORRESPONDENCE

Metformin As an Addition to Conventional Chemotherapy in Breast Cancer

Tal Grenader, Anthony Goldberg, and Linda Shavit
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4110 [Abstract] [PDF]  

CORRESPONDENCE

Cardiovascular Disease With Androgen Deprivation: The (forgotten) Role of Testosterone

Jeanny B. Aragon-Ching
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4078 [Abstract] [PDF]  

CORRESPONDENCE

Aromatase Inhibitors As Adjuvant Therapy for Breast Cancer: Overall Survival Versus Disease-Free Survival As a Primary End Point in Clinical Practice

Alfonso Sánchez-Muñoz, Nuria Ribelles, Antonia Márquez, Elisabeth Pérez-Ruiz, and Emilio Alba
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.3914 [Abstract] [PDF]  

CORRESPONDENCE

Reply to A. Sasse et al

Yu Yang Soon, Martin R. Stockler, Lisa M. Askie, and Michael J. Boyer
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.3757 [Abstract] [PDF]  

CORRESPONDENCE

Duration of Chemotherapy for Metastatic Non–Small-Cell Lung Cancer: More May Be Not Better

Andre D. Sasse, Joao P. Lima, Emma C. Sasse, and Lucas V. Santos
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.1918 [Abstract] [PDF]  

REVIEW ARTICLES

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

Michele Baccarani, Jorge Cortes, Fabrizio Pane, Dietger Niederwieser, Giuseppe Saglio, Jane Apperley, Francisco Cervantes, Michael Deininger, Alois Gratwohl, François Guilhot, Andreas Hochhaus, Mary Horowitz, Timothy Hughes, Hagop Kantarjian, Richard Larson, Jerald Radich, Bengt Simonsson, Richard T. Silver, John Goldman, and Rudiger Hehlmann
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.0779 [Abstract] [PDF]  

EDITORIALS

The Forest and the Trees: Pathways and Proteins As Colorectal Cancer Biomarkers

Monica M. Bertagnolli
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.8013 [Abstract] [PDF]  

CORRESPONDENCE

Reply to N. Magné et al

Michele Y. Halyard, Thomas M. Pisansky, Amylou C. Dueck, Vera J. Suman, Lori J. Pierce, Lawrence J. Solin, Lawrence B. Marks, Nancy Davidson, Silvana Martino, Peter Kaufman, Leila Kutteh, Shaker Dakhil, and Edith A. Perez
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.7767 [Abstract] [PDF]  

CORRESPONDENCE

Impact on Cardiac Toxicity With Trastuzumab and Radiotherapy: The Question Is Still Ongoing

Nicolas Magné, Lionel Védrine, and Cyrus Chargari
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.6918 [Abstract] [PDF]  

CORRESPONDENCE

Reply to J. Dalmau

Sebastian Rauer and Hendrik Veelken
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.6009 [Abstract] [PDF]  

EDITORIALS

Recognition and Treatment of Sleep Disturbances in Cancer

Sonia Ancoli-Israel
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.5993 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Unique Localization of Circulating Tumor Cells in Patients With Hepatic Metastases

Long R. Jiao, Christos Apostolopoulos, Jimmy Jacob, Richard Szydlo, Natalia Johnson, Nicole Tsim, Nagy A. Habib, R. Charles Coombes, and Justin Stebbing
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.5837 [Abstract] [PDF]  

CORRESPONDENCE

Reply to S. Williams et al

Luis Souhami, Kyounghwa Bae, and Howard Sandler
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.5217 [Abstract] [PDF]  

CORRESPONDENCE

Recognizing Paraneoplastic Limbic Encephalitis

Josep Dalmau
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.4822 [Abstract] [PDF]  

BREAST CANCER

Multimodality Screening of High-Risk Women: A Prospective Cohort Study

Susan P. Weinstein, A. Russell Localio, Emily F. Conant, Mark Rosen, Kathleen M. Thomas, and Mitchell D. Schnall
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.4277 [Abstract] [PDF]  

CORRESPONDENCE

Androgen Deprivation Therapy and Prostate Cancer Duration

Scott G. Williams, Tom Pickles, and Mark K. Buyyounouski
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.4137 [Abstract] [PDF]  

MELANOMA

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

Neil N. Senzer, Howard L. Kaufman, Thomas Amatruda, Mike Nemunaitis, Tony Reid, Gregory Daniels, Rene Gonzalez, John Glaspy, Eric Whitman, Kevin Harrington, Howard Goldsweig, Tracey Marshall, Colin Love, Robert Coffin, and John J. Nemunaitis
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.3675 [Abstract] [PDF]  

EDITORIALS

Refining Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: T Stands for Trastuzumab, Tumor Size, and Treatment Strategy

Harold J. Burstein and Eric P. Winer
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.2222 [Abstract] [PDF]  

BIOLOGY OF NEOPLASIA

MicroRNAs in Cancer: Small Molecules With a Huge Impact

Marilena V. Iorio and Carlo M. Croce
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.0317 [Abstract] [PDF]  

CORRESPONDENCE

False-Positive MIBG Scans With Normal Computed Tomography Imaging In Patients With High-Risk Neuroblastoma

Keshan Satharasinghe, Toby N. Trahair, Draga Barbaric, Tracey A. O'Brien, Susan J. Russell, Richard J. Cohn, Glenn M. Marshall, and David S. Ziegler
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.0036 [Abstract] [PDF]  

CORRESPONDENCE

Critical Review of the Determination Process by the Japanese Reviewing Authority in Approving the Additional Efficacy of Fludarabine Phosphate

Hiroto Narimatsu, Giichiro Oiso, Shunsuke Ono, and Masahiro Kami
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.9020 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Phase II Trial of Concurrent Radiation and Weekly Cisplatin Followed by VIPD Chemotherapy in Newly Diagnosed, Stage IE to IIE, Nasal, Extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma Study

Seok Jin Kim, Kihyun Kim, Byung Soo Kim, Chul Yong Kim, Cheolwon Suh, Jooryung Huh, Sang-Wook Lee, Jin Seok Kim, Jaeho Cho, Gyeong-Won Lee, Ki Mun Kang, Hyeon Seok Eom, Hong Ryull Pyo, Yong Chan Ahn, Young Hyeh Ko, and Won Seog Kim
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.8592 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Bilateral Occipital Lobe Invasion in Chronic Lymphocytic Leukemia

Tsunayuki Kakimoto, Tomonori Nakazato, Ryuichiro Hayashi, Hiroyuki Hayashi, Norihide Hayashi, Taijiro Ishiyama, Hiroyuki Asada, and Akaru Ishida
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.8436 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia

Nina S. Kadan-Lottick, Pim Brouwers, David Breiger, Thomas Kaleita, James Dziura, Veronika Northrup, Lu Chen, Megan Nicoletti, Bruce Bostrom, Linda Stork, and Joseph P. Neglia
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.5408 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Sorafenib-Induced Bilateral Osteonecrosis of Femoral Heads

Marielle Guillet, Thomas Walter, Jean-Yves Scoazec, Thierry Vial, Catherine Lombard-Bohas, and Jérôme Dumortier
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.4252 [Abstract] [PDF]  

BREAST CANCER

High Risk of Recurrence for Patients With Breast Cancer Who Have Human Epidermal Growth Factor Receptor 2–Positive, Node-Negative Tumors 1 cm or Smaller

Ana M. Gonzalez-Angulo, Jennifer K. Litton, Kristine R. Broglio, Funda Meric-Bernstam, Ronjay Rakkhit, Fatima Cardoso, Florentia Peintinger, Emer O. Hanrahan, Aysegul Sahin, Merih Guray, Denis Larsimont, Francesco Feoli, Heidi Stranzl, Thomas A. Buchholz, Vicente Valero, Richard Theriault, Martine Piccart-Gebhart, Peter M. Ravdin, Donald A. Berry, and Gabriel N. Hortobagyi
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.2025 [Abstract] [PDF]  

HEAD AND NECK CANCER

Comparative Prognostic Value of HPV16 E6 mRNA Compared With In Situ Hybridization for Human Oropharyngeal Squamous Carcinoma

Wei Shi, Hisayuki Kato, Bayardo Perez-Ordonez, Melania Pintilie, Shaohui Huang, Angela Hui, Brian O'Sullivan, John Waldron, Bernard Cummings, John Kim, Jolie Ringash, Laura A. Dawson, Patrick Gullane, Lillian Siu, Maura Gillison, and Fei-Fei Liu
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.1670 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Hodgkin's Lymphoma of the Breast

Christopher J. Hoimes, Megan K. Selbst, Nelofar Q. Shafi, Michal G. Rose, and Manuel F. Rosado
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.1613 [Abstract] [PDF]  

MELANOMA

Melanoma Prognostic Model Using Tissue Microarrays and Genetic Algorithms

Bonnie E. Gould Rothberg, Aaron J. Berger, Annette M. Molinaro, Antonio Subtil, Michael O. Krauthammer, Robert L. Camp, William R. Bradley, Stephan Ariyan, Harriet M. Kluger, and David L. Rimm
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.8239 [Abstract] [PDF]  

BREAST CANCER

Advanced Breast Cancer and Breast Cancer Mortality in Randomized Controlled Trials on Mammography Screening

Philippe Autier, Clarisse Héry, Jari Haukka, Mathieu Boniol, and Graham Byrnes
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.7041 [Abstract] [PDF]  

PALLIATIVE AND SUPPORTIVE CARE

Patients' Supportive Care Needs Beyond the End of Cancer Treatment: A Prospective, Longitudinal Survey

Jo Armes, Maggie Crowe, Lynne Colbourne, Helen Morgan, Trevor Murrells, Catherine Oakley, Nigel Palmer, Emma Ream, Annie Young, and Alison Richardson
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.5151 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial

Susan D. Richman, Matthew T. Seymour, Philip Chambers, Faye Elliott, Catherine L. Daly, Angela M. Meade, Graham Taylor, Jennifer H. Barrett, and Philip Quirke
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.4295 [Abstract] [PDF]  

HEAD AND NECK CANCER

Effect of Epoetin Alfa on Survival and Cancer Treatment–Related Anemia and Fatigue in Patients Receiving Radical Radiotherapy With Curative Intent for Head and Neck Cancer

Peter J. Hoskin, Martin Robinson, Nicholas Slevin, David Morgan, Kevin Harrington, and Christopher Gaffney
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.3693 [Abstract] [PDF]  

THORACIC ONCOLOGY

Phase II Study of Preoperative Gefitinib in Clinical Stage I Non–Small-Cell Lung Cancer

Humberto Lara-Guerra, Thomas K. Waddell, Maria A. Salvarrey, Anthony M. Joshua, Catherine T. Chung, Narinder Paul, Scott Boerner, Akira Sakurada, Olga Ludkovski, Clement Ma, Jeremy Squire, Geoffrey Liu, Frances A. Shepherd, Ming-Sound Tsao, and Natasha B. Leighl
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.3370 [Abstract] [PDF]  

REVIEW ARTICLES

Understanding the Mechanisms Behind Trastuzumab Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

Neil L. Spector and Kimberly L. Blackwell
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.1507 [Abstract] [PDF]  

BREAST CANCER

Clinical Relevance of HER2 Overexpression/Amplification in Patients With Small Tumor Size and Node-Negative Breast Cancer

Giuseppe Curigliano, Giuseppe Viale, Vincenzo Bagnardi, Luca Fumagalli, Marzia Locatelli, Nicole Rotmensz, Raffaella Ghisini, Marco Colleoni, Elisabetta Munzone, Paolo Veronesi, Stefano Zurrida, Franco Nolè, and Aron Goldhirsch
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.0962 [Abstract] [PDF]  

THORACIC ONCOLOGY

Randomized Phase III Trial of Gemcitabine-Based Chemotherapy With In Situ RRM1 and ERCC1 Protein Levels for Response Prediction in Non–Small-Cell Lung Cancer

Craig Reynolds, Coleman Obasaju, Michael J. Schell, Xueli Li, Zhong Zheng, David Boulware, John R. Caton, Linda C. DeMarco, Mark A. O'Rourke, Gail Shaw Wright, Kristi A. Boehm, Lina Asmar, Jane Bromund, Guangbin Peng, Matthew J. Monberg, and Gerold Bepler
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.21.9766 [Abstract] [PDF]  

REVIEW ARTICLES

Application of Screening Principles to the Reconstructed Breast

Jennifer Zakhireh, Barbara Fowble, and Laura J. Esserman
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.7588 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer

Pierre Laurent-Puig, Anne Cayre, Gilles Manceau, Emmanuel Buc, Jean-Baptiste Bachet, Thierry Lecomte, Philippe Rougier, Astrid Lievre, Bruno Landi, Valérie Boige, Michel Ducreux, Marc Ychou, Fréderic Bibeau, Olivier Bouché, Julia Reid, Steven Stone, and Frédérique Penault-Llorca
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.6796 [Abstract] [PDF]  

BREAST CANCER

Fluorouracil, Epirubicin, and Cyclophosphamide With Either Docetaxel or Vinorelbine, With or Without Trastuzumab, As Adjuvant Treatments of Breast Cancer: Final Results of the FinHer Trial

Heikki Joensuu, Petri Bono, Vesa Kataja, Tuomo Alanko, Riitta Kokko, Raija Asola, Tapio Utriainen, Taina Turpeenniemi-Hujanen, Sirkku Jyrkkiö, Kari Möykkynen, Leena Helle, Seija Ingalsuo, Marjo Pajunen, Mauri Huusko, Tapio Salminen, Päivi Auvinen, Hannu Leinonen, Mika Leinonen, Jorma Isola, and Pirkko-Liisa Kellokumpu-Lehtinen
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.4577 [Abstract] [PDF]  

BREAST CANCER

One-Year Outcomes of a Behavioral Therapy Intervention Trial on Sleep Quality and Cancer-Related Fatigue

Ann M. Berger, Brett R. Kuhn, Lynne A. Farr, Susanna G. Von Essen, Julie Chamberlain, James C. Lynch, and Sangeeta Agrawal
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.20.8306 [Abstract] [PDF] [Data Supplement]  

GENITOURINARY CANCER

Phase II Study of Erlotinib in Patients With Locally Advanced or Metastatic Papillary Histology Renal Cell Cancer: SWOG S0317

Michael S. Gordon, Michael Hussey, Raymond B. Nagle, Primo N. Lara Jr, Philip C. Mack, Janice Dutcher, Wolfram Samlowski, Joseph I. Clark, David I. Quinn, Chong-Xian Pan, and David Crawford
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.18.8821 [Abstract] [PDF]  

BREAST CANCER

Prognostic and Predictive Value of HER2 Extracellular Domain in Metastatic Breast Cancer Treated With Lapatinib and Paclitaxel in a Randomized Phase III Study

Richard S. Finn, Robert Gagnon, Angelo Di Leo, Michael F. Press, Michael Arbushites, and Maria Koehler
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.1763 [Abstract] [PDF] [HTML Page - index.htslp] [Publisher's Note]  

October 26, 2009

CORRESPONDENCE

Reply to R. Memmott et al

Pamela J. Goodwin, Jennifer A. Ligibel, and Vuk Stambolic
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.4284 [Abstract] [PDF]  

CORRESPONDENCE

LKB1 and Mammalian Target of Rapamycin As Predictive Factors for the Anticancer Efficacy of Metformin

Regan M. Memmott and Phillip A. Dennis
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.3963 [Abstract] [PDF]  

EDITORIALS

Contralateral Breast Cancer in BRCA1/BRCA2 Mutation Carriers: The Story of the Other Side

Judy E. Garber and Mehra Golshan
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.1652 [Abstract] [PDF]  

ART OF ONCOLOGY

The Hardest Job in Medicine

Richard C. Frank
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.1371 [Abstract] [PDF]  

CORRESPONDENCE

Reply to G. Ferretti et al

Heinz Ludwig and Alex Fleishman
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.0860 [Abstract] [PDF]  

CORRESPONDENCE

Call for Clarity in the Reporting of Benefit Associated With Anticancer Therapies

Christopher M. Booth, Pavlo Ohorodnyk, and Elizabeth A. Eisenhauer
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.8542 [Abstract] [PDF]  

CORRESPONDENCE

Reply to L.H. Jensen et al and S. Jahn et al

Heather Hampel, Wendy Frankel, and Albert de la Chapelle
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.7015 [Abstract] [PDF]  

CORRESPONDENCE

Molecular Screening for Lynch Syndrome: From Bench to Bedside

Lars Henrik Jensen, Jan Lindebjerg, Steen Kølvraa, and Dorthe G. Crüger
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.6744 [Abstract] [PDF]  

CORRESPONDENCE

Darbepoetin Alfa and History of Thromboembolic Events

Gianluigi Ferretti, Alessandra Felici, and Francesco Cognetti
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.6454 [Abstract] [PDF]  

CORRESPONDENCE

Reply to A. Vazquez-Martin et al

Pamela J. Goodwin, Jennifer A. Ligibel, and Vuk Stambolic
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.6033 [Abstract] [PDF]  

CORRESPONDENCE

If Mammalian Target of Metformin Indirectly Is Mammalian Target of Rapamycin, Then the Insulin-Like Growth Factor-1 Receptor Axis Will Audit the Efficacy of Metformin in Cancer Clinical Trials

Alejandro Vazquez-Martin, Cristina Oliveras-Ferraros, Sonia Del Barco, Begoña Martin-Castillo, and Javier A. Menendez
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.5456 [Abstract] [PDF]  

CORRESPONDENCE

Reply to J. Thiele et al

Peter J. Campbell, David Bareford, Wendy N. Erber, Bridget S. Wilkins, Penny A. Wright, Georgina Buck, Keith Wheatley, Claire N. Harrison, and Anthony R. Green
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.5233 [Abstract] [PDF]  

COMMENTS AND CONTROVERSIES

To Treat Pelvic Nodes or Not: Could the Greater Testicular Scatter Dose From Whole Pelvic Fields Confound Results of Prostate Cancer Trials?

Christopher R. King and Daniel S. Kapp
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.3808 [Abstract] [PDF]  

CORRESPONDENCE

Bone Marrow Fibrosis and Diagnosis of Essential Thrombocythemia

Juergen Thiele, Hans Michael Kvasnicka, James W. Vardiman, Attilio Orazi, Vito Franco, Heinz Gisslinger, Gunnar Birgegard, Martin Griesshammer, and Ayalew Tefferi
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.3485 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine Plus Capecitabine in Patients With Advanced Pancreatic Cancer

David Cunningham, Ian Chau, Deborah D. Stocken, Juan W. Valle, David Smith, William Steward, Peter G. Harper, Janet Dunn, Catrin Tudur-Smith, Julia West, Stephen Falk, Adrian Crellin, Fawzi Adab, Joyce Thompson, Pauline Leonard, Joe Ostrowski, Martin Eatock, Werner Scheithauer, Richard Herrmann, and John P. Neoptolemos
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.2446 [Abstract] [PDF]  

CORRESPONDENCE

Reply to F. Puglisi

Stephen Chan
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.9798 [Abstract] [PDF]  

CORRESPONDENCE

What Does Similarity Mean in Clinical Trials?

Fabio Puglisi
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.9467 [Abstract] [PDF]  

THORACIC ONCOLOGY

Phase II Study of Cisplatin Plus Etoposide and Bevacizumab for Previously Untreated, Extensive-Stage Small-Cell Lung Cancer: Eastern Cooperative Oncology Group Study E3501

Leora Horn, Suzanne E. Dahlberg, Alan B. Sandler, Afshin Dowlati, Dennis F. Moore, John R. Murren, and Joan H. Schiller
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.7545 [Abstract] [PDF] [Publisher's Note]  

DIAGNOSIS IN ONCOLOGY

Solitary Extramedullary Plasmacytoma of the Vocal Cord in an Adolescent

Issai Vanan, Arlene Redner, Mark Atlas, Lorraine Marin, Prajoy Kadkade, Jela Bandovic, and Elaine S. Jaffe
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.7461 [Abstract] [PDF]  

THORACIC ONCOLOGY

Quality of Life Supersedes the Classic Prognosticators for Long-Term Survival in Locally Advanced Non–Small-Cell Lung Cancer: An Analysis of RTOG 9801

Benjamin Movsas, Jennifer Moughan, Linda Sarna, Corey Langer, Maria Werner-Wasik, Nicos Nicolaou, Ritsuko Komaki, Mitchell Machtay, Todd Wasserman, and Deborah Watkins Bruner
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.7420 [Abstract] [PDF]  

COMMENTS AND CONTROVERSIES

Bladder Cancer: Narrowing the Gap Between Evidence and Practice

Maha H.A. Hussain, David P. Wood, Dean F. Bajorin, Bernard H. Bochner, Robert Dreicer, Donald L. Lamm, Michael A. O'Donnell, Arlene O. Siefker-Radtke, Dan Theodorescu, and Colin P. Dinney
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.6901 [Abstract] [PDF]  

GENITOURINARY CANCER

Evaluating the Combined Effect of Comorbidity and Prostate-Specific Antigen Kinetics on the Risk of Death in Men After Prostate-Specific Antigen Recurrence

Jennifer Y. Wo, Ming-Hui Chen, Paul L. Nguyen, Andrew A. Renshaw, Marian J. Loffredo, Philip W. Kantoff, and Anthony V. D'Amico
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.6067 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Bisphosphonate-Related Osteonecrosis of the Jaw and Left Thumb

Raffaele Longo, Maria Angela Castellana, and Giampietro Gasparini
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.4468 [Abstract] [PDF]  

EDITORIALS

Changing the Paradigm in Conducting Randomized Clinical Studies in Advanced Pancreatic Cancer: An Opportunity for Better Clinical Development

Josep Tabernero and Teresa Macarulla
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.3098 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Do Male Lymphoma Survivors Have Impaired Sexual Function?

Cecilie E. Kiserud, Leslie R. Schover, Alv A. Dahl, Alexander Fosså, Trine Bjøro, Jon Håvard Loge, Harald Holte, Ying Yuan, and Sophie D. Fosså
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.2280 [Abstract] [PDF]  

BIOLOGY OF NEOPLASIA

Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology

Ultan McDermott and Jeff Settleman
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.9054 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Tracheal Glomangioma in a Patient With Asthma and Chest Pain

Kathryn L. Parker, Michael D. Zervos, Jessica S. Donington, Pratibha S. Shukla, and Costas S. Bizekis
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.7942 [Abstract] [PDF]  

BREAST CANCER

Phase II Multicenter Trial of Anthracycline Rechallenge With Pegylated Liposomal Doxorubicin Plus Cyclophosphamide for First-Line Therapy of Metastatic Breast Cancer Previously Treated With Adjuvant Anthracyclines

Maureen E. Trudeau, Mark J. Clemons, Louise Provencher, Lawrence Panasci, Louise Yelle, Daniel Rayson, Jean Latreille, Ted Vandenberg, Rakesh Goel, Labib Zibdawi, Yasmin Rahim, and Jean-Francois Pouliot
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.7504 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Quantitative PCR Analysis for Bcl-2/IgH in a Phase III Study of Yttrium-90 Ibritumomab Tiuxetan As Consolidation of First Remission in Patients With Follicular Lymphoma

Lindsey Goff, Karin Summers, Sameena Iqbal, Jens Kuhlmann, Michael Kunz, Tom Louton, Anton Hagenbeek, Franck Morschhauser, Barbara Putz, Andrew Lister, and Ama Rohatiner
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.6258 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Age-Specific Differences in Oncogenic Pathway Dysregulation and Anthracycline Sensitivity in Patients With Acute Myeloid Leukemia

Arati V. Rao, Peter J.M. Valk, Klaus H. Metzeler, Chaitanya R. Acharya, Sascha A. Tuchman, Marvaretta M. Stevenson, David A. Rizzieri, Ruud Delwel, Christian Buske, Stefan K. Bohlander, Anil Potti, and Bob Löwenberg
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.2547 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

VMP (Bortezomib, Melphalan, and Prednisone) Is Active and Well Tolerated in Newly Diagnosed Patients With Multiple Myeloma With Moderately Impaired Renal Function, and Results in Reversal of Renal Impairment: Cohort Analysis of the Phase III VISTA Study

Meletios A. Dimopoulos, Paul G. Richardson, Rudolf Schlag, Nuriet K. Khuageva, Ofer Shpilberg, Efstathios Kastritis, Martin Kropff, Maria T. Petrucci, Michel Delforge, Julia Alexeeva, Rik Schots, Tamás Masszi, Maria-Victoria Mateos, William Deraedt, Kevin Liu, Andrew Cakana, Helgi van de Velde, and Jesús F. San Miguel
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.2232 [Abstract] [PDF]  

HEALTH SERVICES AND OUTCOMES

Evidence-Based Approach to the Introduction of Positron Emission Tomography in Ontario, Canada

William K. Evans, Andreas Laupacis, Karen Y. Gulenchyn, Les Levin, and Mark Levine
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.1614 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Randomized Phase II Study of Gemcitabine Administered at a Fixed Dose Rate or in Combination With Cisplatin, Docetaxel, or Irinotecan in Patients With Metastatic Pancreatic Cancer: CALGB 89904

Matthew H. Kulke, Margaret A. Tempero, Donna Niedzwiecki, Donna R. Hollis, Hedy L. Kindler, Michael Cusnir, Peter C. Enzinger, Stefan M. Gorsch, Richard M. Goldberg, and Robert J. Mayer
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.1309 [Abstract] [PDF]  

SPECIAL ARTICLES

Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment

Philip A. Philip, Margaret Mooney, Deborah Jaffe, Gail Eckhardt, Malcolm Moore, Neal Meropol, Leisha Emens, Eileen O'Reilly, Murray Korc, Lee Ellis, Jacqueline Benedetti, Mace Rothenberg, Christopher Willett, Margaret Tempero, Andrew Lowy, James Abbruzzese, Diane Simeone, Sunil Hingorani, Jordan Berlin, and Joel Tepper
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.21.9022 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial

Michael S. Braun, Susan D. Richman, Lindsay Thompson, Catherine L. Daly, Angela M. Meade, Julian W. Adlard, James M. Allan, Mahesh K.B. Parmar, Philip Quirke, and Matthew T. Seymour
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.21.6283 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Dose Finding and Early Efficacy Study of Gemcitabine Plus Capecitabine in Combination With Bevacizumab Plus Erlotinib in Advanced Pancreatic Cancer

Naureen Starling, David Watkins, David Cunningham, Janet Thomas, Janine Webb, Gina Brown, Karen Thomas, Jacqui Oates, and Ian Chau
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.21.5384 [Abstract] [PDF]  

GENITOURINARY CANCER

Prospective Study of Prostate Tumor Angiogenesis and Cancer-Specific Mortality in the Health Professionals Follow-Up Study

Lorelei A. Mucci, Anna Powolny, Edward Giovannucci, Zhiming Liao, Stacey A. Kenfield, Rulong Shen, Meir J. Stampfer, and Steven K. Clinton
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.20.8876 [Abstract] [PDF]  

BREAST CANCER

Contralateral Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Monika K. Graeser, Christoph Engel, Kerstin Rhiem, Dorothea Gadzicki, Ulrich Bick, Karin Kast, Ursula G. Froster, Bettina Schlehe, Astrid Bechthold, Norbert Arnold, Sabine Preisler-Adams, Carolin Nestle-Kraemling, Mohammad Zaino, Markus Loeffler, Marion Kiechle, Alfons Meindl, Dominic Varga, and Rita K. Schmutzler
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.19.9430 [Abstract] [PDF]  

GENITOURINARY CANCER

Health-Related Quality of Life in Long-Term Survivors of Testicular Cancer

Philip Blach Rossen, Anette Fischer Pedersen, Robert Zachariae, and Hans von der Maase
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.19.6931 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer

Franck Pagès, Amos Kirilovsky, Bernhard Mlecnik, Martin Asslaber, Marie Tosolini, Gabriela Bindea, Christine Lagorce, Philippe Wind, Florence Marliot, Patrick Bruneval, Kurt Zatloukal, Zlatko Trajanoski, Anne Berger, Wolf-Herman Fridman, and Jérôme Galon
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.19.6147 [Abstract] [PDF]  

October 19, 2009

COMMENTS AND CONTROVERSIES

Toward Efficient Trials in Colorectal Cancer: The ARCAD Clinical Trials Program

Aimery de Gramont, Daniel G. Haller, Daniel J. Sargent, Josep Tabernero, Alastair Matheson, and Richard L. Schilsky
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.2544 [Abstract] [PDF]  

CORRESPONDENCE

Reply to Lin et al

Luis Souhami, Kyounghwa Bae, and Howard M. Sandler
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.2221 [Abstract] [PDF]  

CORRESPONDENCE

Selection Bias Clouds Apparent Benefit of Longer Hormone Duration

Kevin Lin, Steve P. Lee, and Michael L. Steinberg
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0969 [Abstract] [PDF]  

CORRESPONDENCE

Reply to S. Nagai et al

David Grimwade, Jelena V. Jovanovic, Robert K. Hills, Ellen Solomon, Francesco Lo-Coco, Keith Wheatley, and Alan K. Burnett
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0522 [Abstract] [PDF]  

CORRESPONDENCE

Revisiting the Concept of Phenotypically Distinct Malignant Pancreatic Stem-Cell Subsets Based on Limiting Dilution Transplantation Assays

Thierry Bonnefoix and Mary Callanan
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0282 [Abstract] [PDF]  

CORRESPONDENCE

How Should We Prevent Hematologic Relapse of Acute Promyelocytic Leukemia?

Sumimasa Nagai, Tsuyoshi Takahashi, and Mineo Kurokawa
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.9995 [Abstract] [PDF]  

CORRESPONDENCE

Reply to P. Prassopoulos et al

Shauna L. Hillman and Daniel J. Sargent
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.6736 [Abstract] [PDF]  

CORRESPONDENCE

Metastatic Disease Response to Treatment: How Many Lesions to Measure?

Panos Prassopoulos and Michael Mantatzis
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.4004 [Abstract] [PDF]  

CORRESPONDENCE

Reply to V. Arena et al

Stefano Zurrida, Giuseppe Viale, and Umberto Veronesi
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.3253 [Abstract] [PDF]  

CORRESPONDENCE

Breast Cancer Classification: The Dialogue Is Open

Vincenzo Arena, Ilaria Pennacchia, Giovanni Monego, Arnaldo Carbone, and Arnaldo Capelli
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.2461 [Abstract] [PDF]  

THORACIC ONCOLOGY

Phase II Trial of Pemetrexed Plus Bevacizumab for Second-Line Therapy of Patients With Advanced Non–Small-Cell Lung Cancer: NCCTG and SWOG Study N0426

Alex A. Adjei, Sumithra J. Mandrekar, Grace K. Dy, Julian R. Molina, Araba A. Adjei, David R. Gandara, Katie L. Allen Ziegler, Philip J. Stella, Kendrith M. Rowland Jr, Steven E. Schild, and Ralph G. Zinner
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.6406 [Abstract] [PDF]  

ASCO SPECIAL ARTICLES

American Society of Clinical Oncology 2009 Clinical Evidence Review on Radiofrequency Ablation of Hepatic Metastases From Colorectal Cancer

Sandra L. Wong, Pamela B. Mangu, Michael A. Choti, Todd S. Crocenzi, Gerald D. Dodd III, Gary S. Dorfman, Cathy Eng, Yuman Fong, Andrew F. Giusti, David Lu, Thomas A. Marsland, Rob Michelson, Graeme J. Poston, Deborah Schrag, Jerome Seidenfeld, and Al B. Benson III
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.4450 [Abstract] [PDF]  

GYNECOLOGIC CANCER

Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes

Kristel Van Calsteren, Liesbeth Heyns, Frank De Smet, Liesbet Van Eycken, Mina Mhallem Gziri, Willemijn Van Gemert, Michael Halaska, Ignace Vergote, Nelleke Ottevanger, and Frédéric Amant
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.2801 [Abstract] [PDF]  

ECONOMIC ANALYSIS

Costs and Benefits of the National Cancer Institute Central Institutional Review Board

Todd H. Wagner, Christine Murray, Jacquelyn Goldberg, Jeanne M. Adler, and Jeffrey Abrams
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.2470 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

Suicide Ideation in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Christopher J. Recklitis, Lisa R. Diller, Xiaochun Li, Julie Najita, Leslie L. Robison, and Lonnie Zeltzer
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.22.8635 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

Outcome of Patients Treated for Relapsed or Refractory Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia Consortium Study

Richard H. Ko, Lingyun Ji, Phillip Barnette, Bruce Bostrom, Raymond Hutchinson, Elizabeth Raetz, Nita L. Seibel, Clare J. Twist, Elena Eckroth, Richard Sposto, Paul S. Gaynon, and Mignon L. Loh
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.22.2950 [Abstract] [PDF]  

BREAST CANCER

Feasibility Trial of Letrozole in Combination With Bevacizumab in Patients With Metastatic Breast Cancer

Tiffany A. Traina, Hope S. Rugo, James F. Caravelli, Sujata Patil, Benjamin Yeh, Michele E. Melisko, John W. Park, Stephanie Geneus, Matthew Paulson, Jill Grothusen, Andrew D. Seidman, Monica Fornier, Diana Lake, Chau Dang, Mark Robson, Maria Theodoulou, Carlos D. Flombaum, Larry Norton, Clifford A. Hudis, and Maura N. Dickler
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.21.8784 [Abstract] [PDF]  

TREATMENT-RELATED COMPLICATIONS

Clinically Driven Diagnostic Antifungal Approach in Neutropenic Patients: A Prospective Feasibility Study

Corrado Girmenia, Alessandra Micozzi, Giuseppe Gentile, Stefania Santilli, Eva Arleo, Luisa Cardarelli, Saveria Capria, Clara Minotti, Claudio Cartoni, Simonetta Brocchieri, Vito Guerrisi, Giovanna Meloni, Robin Foà, and Pietro Martino
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.21.8032 [Abstract] [PDF]  

GYNECOLOGIC CANCER

Preventing Future Cancers by Testing Women With Ovarian Cancer for BRCA Mutations

Janice S. Kwon, Molly S. Daniels, Charlotte C. Sun, and Karen H. Lu
JCO published online October 19, 2009, DOI:10.1200/JCO.2008.21.4684 [Abstract] [PDF]  

GENITOURINARY CANCER

Randomized Phase III Trial on Gemcitabine Versus Mytomicin in Recurrent Superficial Bladder Cancer: Evaluation of Efficacy and Tolerance

Raffaele Addeo, Michele Caraglia, Sergio Bellini, Alberto Abbruzzese, Bruno Vincenzi, Liliana Montella, Antonio Miragliuolo, Rosario Guarrasi, Michele Lanna, Gregorio Cennamo, Vincenzo Faiola, and Salvatore Del Prete
JCO published online October 19, 2009, DOI:10.1200/JCO.2008.20.8199 [Abstract] [PDF]  

October 13, 2009

EDITORIALS

Predicting the Risk of Axillary Nodal Metastases and Their Use in Selecting Breast Surgery Options

Lisa K. Jacobs, Charles M. Balch, and Seng-jaw Soong
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.24.4525 [Abstract] [PDF]  

EDITORIALS

Axillary Reverse Mapping to Prevent Lymphedema After Breast Cancer Surgery: Defining the Limits of the Concept

Seema A. Khan
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.24.3311 [Abstract] [PDF]  

REVIEW ARTICLES

Ultimate Fate of Oncology Drugs Approved by the US Food and Drug Administration Without a Randomized Trial

Apostolia-Maria Tsimberidou, Fadi Braiteh, David J. Stewart, and Razelle Kurzrock
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.6018 [Abstract] [PDF]  

GYNECOLOGIC CANCER

Cediranib, an Oral Inhibitor of Vascular Endothelial Growth Factor Receptor Kinases, Is an Active Drug in Recurrent Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer

Ursula A. Matulonis, Suzanne Berlin, Percy Ivy, Karin Tyburski, Carolyn Krasner, Corrine Zarwan, Anna Berkenblit, Susana Campos, Neil Horowitz, Stephen A. Cannistra, Hang Lee, Julie Lee, Maria Roche, Margaret Hill, Christin Whalen, Laura Sullivan, Chau Tran, Benjamin D. Humphreys, and Richard T. Penson
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.2777 [Abstract] [PDF]  

THORACIC ONCOLOGY

Polymorphisms in the CASPASE Genes and Survival in Patients With Early-Stage Non–Small-Cell Lung Cancer

Seung Soo Yoo, Jin Eun Choi, Won-Kee Lee, Yi-Young Choi, Sin Kam, Min Jung Kim, Hyo-Sung Jeon, Eung-Bae Lee, Dong Sun Kim, Myung-Hoon Lee, In-San Kim, Sanghoon Jheon, and Jae Yong Park
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.1738 [Abstract] [PDF]  

HEALTH SERVICES AND OUTCOMES

Physician Referral for Fertility Preservation in Oncology Patients: A National Study of Practice Behaviors

Gwendolyn P. Quinn, Susan T. Vadaparampil, Ji-Hyun Lee, Paul B. Jacobsen, Gerold Bepler, Johnathan Lancaster, David L. Keefe, and Terrance L. Albrecht
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.0250 [Abstract] [PDF] [Data Supplement]  

PALLIATIVE AND SUPPORTIVE CARE

Prognostic Acceptance and the Well-Being of Patients Receiving Palliative Care for Cancer

Genevieve N. Thompson, Harvey M. Chochinov, Keith G. Wilson, Christine J. McPherson, Srini Chary, Fiona M. O'Shea, David R. Kuhl, Robin L. Fainsinger, Pierre R. Gagnon, and Karen A. Macmillan
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.9799 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Incidental Detection of Acute Lymphoblastic Leukemia on [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography

Daisuke Ennishi, Yoshinobu Maeda, Masami Niiya, Katsuji Shinagawa, and Mitsune Tanimoto
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.7769 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Phase II Study of Flavopiridol in Relapsed Chronic Lymphocytic Leukemia Demonstrating High Response Rates in Genetically High-Risk Disease

Thomas S. Lin, Amy S. Ruppert, Amy J. Johnson, Beth Fischer, Nyla A. Heerema, Leslie A. Andritsos, Kristie A. Blum, Joseph M. Flynn, Jeffrey A. Jones, Weihong Hu, Mollie E. Moran, Sarah M. Mitchell, Lisa L. Smith, Amy J. Wagner, Chelsey A. Raymond, Larry J. Schaaf, Mitch A. Phelps, Miguel A. Villalona-Calero, Michael R. Grever, and John C. Byrd
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.6944 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Paraneoplastic Acrokeratosis (Bazex Syndrome) in Lung Cancer

Antonio Crucitti, Claudio Feliciani, Ugo Grossi, Antonio La Greca, Venanzio Porziella, Piero Giustacchini, Maria Teresa Congedo, Pietrangelo Fronterré, and Pierluigi Maria Granone
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.6852 [Abstract] [PDF]  

CLINICAL TRIALS

Role of Sensitivity Analyses in Assessing Progression-Free Survival in Late-Stage Oncology Trials

Suman Bhattacharya, Gwen Fyfe, Robert J. Gray, and Daniel J. Sargent
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.4329 [Abstract] [PDF]  

COMMENTS AND CONTROVERSIES

Incremental Advance or Seismic Shift? The Need to Raise the Bar of Efficacy for Drug Approval

Alberto Sobrero and Paolo Bruzzi
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.4162 [Abstract] [PDF]  

BREAST CANCER

Extensive Nodal Disease May Impair Axillary Reverse Mapping in Patients With Breast Cancer

Riccardo Ponzone, Nicoletta Tomasi Cont, Furio Maggiorotto, Elisa Cassina, Paola Mininanni, Nicoletta Biglia, and Piero Sismondi
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.1846 [Abstract] [PDF]  

BREAST CANCER

Prospective Multicenter Comparison of Models to Predict Four or More Involved Axillary Lymph Nodes in Patients With Breast Cancer With One to Three Metastatic Sentinel Lymph Nodes

Gabrielle Werkoff, Eric Lambaudie, Eric Fondrinier, Jean Levêque, Fréderic Marchal, Michele Uzan, Emmanuel Barranger, François Guillemin, Emile Darai, Serge Uzan, Gilles Houvenaeghel, Roman Rouzier, and Charles Coutant
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.21.9139 [Abstract] [PDF]  

EPIDEMIOLOGY

Mobile Phone Use and Risk of Tumors: A Meta-Analysis

Seung-Kwon Myung, Woong Ju, Diana D. McDonnell, Yeon Ji Lee, Gene Kazinets, Chih-Tao Cheng, and Joel M. Moskowitz
JCO published online October 13, 2009, DOI:10.1200/JCO.2008.21.6366 [Abstract] [PDF]  

GENITOURINARY CANCER

Prognostic Factors for Overall Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Vascular Endothelial Growth Factor–Targeted Agents: Results From a Large, Multicenter Study

Daniel Y.C. Heng, Wanling Xie, Meredith M. Regan, Mark A. Warren, Ali Reza Golshayan, Chakshu Sahi, Bernhard J. Eigl, J. Dean Ruether, Tina Cheng, Scott North, Peter Venner, Jennifer J. Knox, Kim N. Chi, Christian Kollmannsberger, David F. McDermott, William K. Oh, Michael B. Atkins, Ronald M. Bukowski, Brian I. Rini, and Toni K. Choueiri
JCO published online October 13, 2009, DOI:10.1200/JCO.2008.21.4809 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Achievement of at Least Very Good Partial Response Is a Simple and Robust Prognostic Factor in Patients With Multiple Myeloma Treated With High-Dose Therapy: Long-Term Analysis of the IFM 99-02 and 99-04 Trials

Jean-Luc Harousseau, Herve Avet-Loiseau, Michel Attal, Catherine Charbonnel, Frederic Garban, Cyrille Hulin, Mauricette Michallet, Thierry Facon, Laurent Garderet, Gerald Marit, Nicolas Ketterer, Thierry Lamy, Laurent Voillat, Francois Guilhot, Chantal Doyen, Claire Mathiot, and Philippe Moreau
JCO published online October 13, 2009, DOI:10.1200/JCO.2008.21.1060 [Abstract] [PDF]  

October 5, 2009

EDITORIALS

What's Race Got to Do With It?

Ramona Rhodes and Joan M. Teno
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.24.2206 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Phase I/II Study of Concurrent Chemoradiotherapy for Localized Nasal Natural Killer/T-Cell Lymphoma: Japan Clinical Oncology Group Study JCOG0211

Motoko Yamaguchi, Kensei Tobinai, Masahiko Oguchi, Naoki Ishizuka, Yukio Kobayashi, Yasushi Isobe, Kenichi Ishizawa, Nobuo Maseki, Kuniaki Itoh, Noriko Usui, Izumi Wasada, Tomohiro Kinoshita, Koichi Ohshima, Yoshihiro Matsuno, Takashi Terauchi, Shigeru Nawano, Satoshi Ishikura, Yoshikazu Kagami, Tomomitsu Hotta, and Kazuo Oshimi
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.8295 [Abstract] [PDF]  

BREAST CANCER

Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

Leisha A. Emens, Justin M. Asquith, James M. Leatherman, Barry J. Kobrin, Silvia Petrik, Marina Laiko, Joy Levi, Maithili M. Daphtary, Barbara Biedrzycki, Antonio C. Wolff, Vered Stearns, Mary L. Disis, Xiaobu Ye, Steven Piantadosi, John H. Fetting, Nancy E. Davidson, and Elizabeth M. Jaffee
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.3494 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Practical Application of a Calculator for Conditional Survival in Colon Cancer

George J. Chang, Chung-Yuan Hu, Cathy Eng, John M. Skibber, and Miguel A. Rodriguez-Bigas
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.1860 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Alpha-Fetoprotein Response After Locoregional Therapy for Hepatocellular Carcinoma: Oncologic Marker of Radiologic Response, Progression, and Survival

Ahsun Riaz, Robert K. Ryu, Laura M. Kulik, Mary F. Mulcahy, Robert J. Lewandowski, Jeet Minocha, Saad M. Ibrahim, Kent T. Sato, Talia Baker, Frank H. Miller, Steven Newman, Reed Omary, Michael Abecassis, Al B. Benson III, and Riad Salem
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.1282 [Abstract] [PDF]  

NEUROONCOLOGY

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

Michael Weller, Jörg Felsberg, Christian Hartmann, Hilmar Berger, Joachim P. Steinbach, Johannes Schramm, Manfred Westphal, Gabriele Schackert, Matthias Simon, Jörg C. Tonn, Oliver Heese, Dietmar Krex, Guido Nikkhah, Torsten Pietsch, Otmar Wiestler, Guido Reifenberger, Andreas von Deimling, and Markus Loeffler
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.0805 [Abstract] [PDF]  

PALLIATIVE AND SUPPORTIVE CARE

Racial Differences in Predictors of Intensive End-of-Life Care in Advanced Cancer Patients

Elizabeth Trice Loggers, Paul K. Maciejewski, Elizabeth Paulk, Susan DeSanto-Madeya, Matthew Nilsson, Kasisomayajula Viswanath, Alexi Anne Wright, Tracy A. Balboni, Jennifer Temel, Heather Stieglitz, Susan Block, and Holly G. Prigerson
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.4733 [Abstract] [PDF]  

BREAST CANCER

Underweight and Breast Cancer Recurrence and Death: A Report From the Korean Breast Cancer Society

Hyeong-Gon Moon, Wonshik Han, and Dong-Young Noh
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.4436 [Abstract] [PDF]  

HEAD AND NECK CANCER

Reporting of Time-to-Event End Points and Tracking of Failures in Randomized Trials of Radiotherapy With or Without Any Concomitant Anticancer Agent for Locally Advanced Head and Neck Cancer

Christophe Le Tourneau, Stefan Michiels, Hui K. Gan, and Lillian L. Siu
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.3685 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Spontaneous Remission in a Patient With t(4;14) Translocation Multiple Myeloma

Noemi Puig, Suzanne Trudel, Jonathan J. Keats, Zhi Hua Li, Esteban Braggio, Gregory J. Ahmann, Seda Zeng, Rafael Fonseca, and Vishal Kukreti
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.0392 [Abstract] [PDF] [Data Supplement]  

DIAGNOSIS IN ONCOLOGY

Recognition of a New Chemotherapeutic Vesicant: Trabectedin (Ecteinascidin-743) Extravasation With Skin and Soft Tissue Damage

Todd A. Theman, Tristan L. Hartzell, Indranil Sinha, Kathleen Polson, Jeffrey Morgan, George D. Demetri, Dennis P. Orgill, and Suzanne George
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.21.6473 [Abstract] [PDF]  

REVIEW ARTICLES

Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management

Meagan Elizabeth Brennan, Nehmat Houssami, Sarah Lord, Petra Macaskill, Les Irwig, J. Michael Dixon, Ruth M.L. Warren, and Stefano Ciatto
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.21.5756 [Abstract] [PDF]  

BREAST CANCER

Novel Breast Tissue Feature Strongly Associated With Risk of Breast Cancer

Kevin P. McKian, Carol A. Reynolds, Daniel W. Visscher, Aziza Nassar, Derek C. Radisky, Robert A. Vierkant, Amy C. Degnim, Judy C. Boughey, Karthik Ghosh, Stephanie S. Anderson, Douglas Minot, Jill L. Caudill, Celine M. Vachon, Marlene H. Frost, V. Shane Pankratz, and Lynn C. Hartmann
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.21.5079 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

"Trying to Be a Good Parent" As Defined By Interviews With Parents Who Made Phase I, Terminal Care, and Resuscitation Decisions for Their Children

Pamela S. Hinds, Linda L. Oakes, Judy Hicks, Brent Powell, Deo Kumar Srivastava, Sheri L. Spunt, JoAnn Harper, Justin N. Baker, Nancy K. West, and Wayne L. Furman
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.20.0204 [Abstract] [PDF]  

September 28, 2009

EDITORIALS

Stop and Go: Yes or No?

Howard S. Hochster
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.24.5209 [Abstract] [PDF]  

EDITORIALS

Relapse/Refractory Myeloma Patient: Potential Treatment Guidelines

Jesús F. San Miguel
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.24.3683 [Abstract] [PDF]  

EDITORIALS

How to Treat Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Amplified Breast Cancer

Javier Cortes and José Baselga
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.8089 [Abstract] [PDF]  

PHASE I AND CLINICAL PHARMACOLOGY

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1

Anthony W. Tolcher, John Sarantopoulos, Amita Patnaik, Kyriakos Papadopoulos, Chia-Chi Lin, Jordi Rodon, Barbara Murphy, Bruce Roth, Ian McCaffery, Kevin S. Gorski, Brianne Kaiser, Min Zhu, Hongjie Deng, Greg Friberg, and Igor Puzanov
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.6745 [Abstract] [PDF]  

CORRESPONDENCE

Biased Hormonal Therapy Duration Analysis Makes Results Uninterpretable

Catherine M. Tangen, Bryan H. Goldman, Gregory P. Swanson, and Ian M. Thompson
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.6000 [Abstract] [PDF]  

CORRESPONDENCE

Reply to L. Collette et al and C.M. Tangen et al

Luis Souhami, Kyounghwa Bae, and Howard Sandler
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.5341 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Can Chemotherapy Be Discontinued in Unresectable Metastatic Colorectal Cancer? The GERCOR OPTIMOX2 Study

Benoist Chibaudel, Frédérique Maindrault-Goebel, Gérard Lledo, Laurent Mineur, Thierry André, Mostepha Bennamoun, May Mabro, Pascal Artru, Elisabeth Carola, Michel Flesch, Olivier Dupuis, Philippe Colin, Annette K. Larsen, Pauline Afchain, Christophe Tournigand, Christophe Louvet, and Aimery de Gramont
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.4344 [Abstract] [PDF]  

BREAST CANCER

Lapatinib Combined With Letrozole Versus Letrozole and Placebo As First-Line Therapy for Postmenopausal Hormone Receptor–Positive Metastatic Breast Cancer

Stephen Johnston, John Pippen Jr, Xavier Pivot, Mikhail Lichinitser, Saeed Sadeghi, Veronique Dieras, Henry Leonidas Gomez, Gilles Romieu, Alexey Manikhas, M. John Kennedy, Michael F. Press, Julie Maltzman, Allison Florance, Lisa O'Rourke, Cristina Oliva, Steven Stein, and Mark Pegram
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.3734 [Abstract] [PDF]  

CORRESPONDENCE

Selection Bias Is Not a Good Reason for Advising More Than 5 Years of Adjuvant Hormonal Therapy for All Patients With Locally Advanced Prostate Cancer Treated With Radiotherapy

Laurence Collette and Urs E. Studer
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.3601 [Abstract] [PDF]  

THORACIC ONCOLOGY

Genetic Abnormalities of the EGFR Pathway in African American Patients With Non–Small-Cell Lung Cancer

Rom S. Leidner, Pingfu Fu, Bradley Clifford, Ayad Hamdan, Cheng Jin, Rosana Eisenberg, Titus J. Boggon, Margaret Skokan, Wilbur A. Franklin, Federico Cappuzzo, Fred R. Hirsch, Marileila Varella-Garcia, and Balazs Halmos
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.1431 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Dynamic Model for Predicting Death Within 12 Months in Patients With Primary or Post–Polycythemia Vera/Essential Thrombocythemia Myelofibrosis

Constantine S. Tam, Hagop Kantarjian, Jorge Cortes, Alice Lynn, Sherry Pierce, Lingsha Zhou, Michael J. Keating, Deborah A. Thomas, and Srdan Verstovsek
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.8833 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Geographic Distribution of Lapatinib-Induced Skin Rash: Sparing of Abdominal Skin Persists in the Transverse Rectus Abdominis Myocutaneous Flap

Nancy U. Lin, Elizabeth Kasparian, Daniel E. Morganstern, and Clair Beard
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.7868 [Abstract] [PDF]  

HEALTH SERVICES AND OUTCOMES

To Tell or Not to Tell: The Community Wants to Know About Expensive Anticancer Drugs As a Potential Treatment Option

Linda Mileshkin, Penelope E. Schofield, Michael Jefford, Emilia Agalianos, Michele Levine, Alan Herschtal, Julian Savulescu, Jacqui Ann Thomson, and John R. Zalcberg
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.7793 [Abstract] [PDF] [Data Supplement]  

HEMATOLOGIC MALIGNANCIES

Immuno–Fluorescence In Situ Hybridization Index Predicts Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A GELA Study

Christiane Copie-Bergman, Philippe Gaulard, Karen Leroy, Josette Briere, Maryse Baia, Jean-Philippe Jais, Gilles A. Salles, Françoise Berger, Corinne Haioun, Herve Tilly, Jean-François Emile, Alison H. Banham, Nicolas Mounier, Christian Gisselbrecht, Pierre Feugier, Bertrand Coiffier, and Thierry J. Molina
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.7058 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Rapid Clinical Deterioration and Leukemoid Reaction After Treatment of Urothelial Carcinoma of the Bladder: Possible Effect of Granulocyte Colony-Stimulating Factor

Francisco A. Perez, Corinne L. Fligner, and Evan Y. Yu
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.4931 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

Survival After Second Primary Neoplasms of the Brain or Spinal Cord in Survivors of Childhood Cancer: Results From the British Childhood Cancer Survivor Study

Aliki J. Taylor, Clare Frobisher, David W. Ellison, Raoul C. Reulen, David L. Winter, Roger E. Taylor, Charles A. Stiller, Emma R. Lancashire, Edward C.G. Tudor, Christina Baggott, Shaun May, and Mike M. Hawkins
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.4386 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Multicenter, Phase I, Dose-Escalation Trial of Lenalidomide Plus Bortezomib for Relapsed and Relapsed/Refractory Multiple Myeloma

Paul G. Richardson, Edie Weller, Sundar Jagannath, David E. Avigan, Melissa Alsina, Robert L. Schlossman, Amitabha Mazumder, Nikhil C. Munshi, Irene M. Ghobrial, Deborah Doss, Diane L. Warren, Laura E. Lunde, Mary McKenney, Carol Delaney, Constantine S. Mitsiades, Teru Hideshima, William Dalton, Robert Knight, Dixie-Lee Esseltine, and Kenneth C. Anderson
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.2679 [Abstract] [PDF]  

GENITOURINARY CANCER

Randomized Phase II/III Trial Assessing Gemcitabine/Carboplatin and Methotrexate/Carboplatin/Vinblastine in Patients With Advanced Urothelial Cancer "Unfit" for Cisplatin-Based Chemotherapy: Phase II—Results of EORTC Study 30986

Maria De Santis, Joaquim Bellmunt, Graham Mead, J. Martijn Kerst, Michael Leahy, Pablo Maroto, Iwona Skoneczna, Sandrine Marreaud, Ronald de Wit, and Richard Sylvester
JCO published online September 28, 2009, DOI:10.1200/JCO.2008.21.4924 [Abstract] [PDF]  

MELANOMA

Targeted High-Resolution Ultrasound Is Not an Effective Substitute for Sentinel Lymph Node Biopsy in Patients With Primary Cutaneous Melanoma

Amira Sanki, Roger F. Uren, Marc Moncrieff, Kayla L. Tran, Richard A. Scolyer, Hui-Yi Lin, and John F. Thompson
JCO published online September 28, 2009, DOI:10.1200/JCO.2008.21.4882 [Abstract] [PDF]  

BREAST CANCER

Trastuzumab Plus Anastrozole Versus Anastrozole Alone for the Treatment of Postmenopausal Women With Human Epidermal Growth Factor Receptor 2–Positive, Hormone Receptor–Positive Metastatic Breast Cancer: Results From the Randomized Phase III TAnDEM Study

Bella Kaufman, John R. Mackey, Michael R. Clemens, Poonamalle P. Bapsy, Ashok Vaid, Andrew Wardley, Sergei Tjulandin, Michaela Jahn, Michaela Lehle, Andrea Feyereislova, Cédric Révil, and Alison Jones
JCO published online September 28, 2009, DOI:10.1200/JCO.2008.20.6847 [Abstract] [PDF]  

August 24, 2009

ART OF ONCOLOGY

The Homecoming

Navneet S. Majhail
JCO published online August 24, 2009, DOI:10.1200/JCO.2009.24.4681 [Abstract] [PDF]  

August 17, 2009

GASTROINTESTINAL CANCER

Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer

John A. Chabot, Wei-Yann Tsai, Robert L. Fine, Chunxia Chen, Carolyn K. Kumah, Karen A. Antman, and Victor R. Grann
JCO published online August 17, 2009, DOI:10.1200/JCO.2009.22.8429 [Abstract] [PDF]  

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